Kerala Surgical Journal

: 2021  |  Volume : 27  |  Issue : 2  |  Page : 111--115

Alterations in liver function test following laparoscopic cholecystectomy

M Anjin Anand, Joji I Maliekal 
 Department of General Surgery, MES Medical College, Kolathur, Kerala, India

Correspondence Address:
M Anjin Anand
Department of General Surgery, MES Medical College, Perinthalmanna, Kolathur - 679 322, Kerala

Introduction: CO2 pneumoperitoneum induced increased intra-abdominal pressure during laparoscopic procedures produces transient reduction in hepatic blood flow liver enzyme elevation. Aims and Objectives: The aim of this study is to study the alteration of liver function test (LFT) parameters such as aspartate aminotransferase/serum glutamic-oxaloacetic transaminase (SGOT), alanine-aminotransferase/serum glutamic-pyruvic transaminase (SGPT), alkaline phosphatase (ALP) and serum bilirubin (total and direct) in patients undergoing laparoscopic cholecystectomy. Materials and Methods: A prospective, cross-sectional study was conducted. The sample size was 50. Data collected were analysed using the SSPS software version 17. Results: Three quarters were females. The mean age of the study population was 48.5 ± 13.1 years, males having higher mean age of 57.0 ± 8.5 years compared to 45.5 ± 13.2 years for females. The SGOT, SGPT, ALP and bilirubin levels were significantly increased on the next day of surgery. There was a significant positive correlation between SGOT and SGPT levels on day 1 to the increased duration of pneumoperitoneum with correlation coefficient of 0.859 and 0.449, respectively. SGOT and SGPT levels were increased significantly in 61–80 years age group. Conclusion: The duration of pneumoperitoneum had a great effect on the LFT changes after surgery. Age influenced changes in SGOT and SGPT levels.

How to cite this article:
Anand M A, Maliekal JI. Alterations in liver function test following laparoscopic cholecystectomy.Kerala Surg J 2021;27:111-115

How to cite this URL:
Anand M A, Maliekal JI. Alterations in liver function test following laparoscopic cholecystectomy. Kerala Surg J [serial online] 2021 [cited 2022 Aug 10 ];27:111-115
Available from:;year=2021;volume=27;issue=2;spage=111;epage=115;aulast=Anand;type=0