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Year : 2020  |  Volume : 26  |  Issue : 2  |  Page : 131-134

The phenomenon of dedifferentiation: Understanding its effect on the post-operative management of papillary thyroid carcinomas

KIMS Cancer Center, Thiruvananthapuram, Kerala, India

Correspondence Address:
Dr. Sandeep Babu Bhaskaran Pillai
14 Beaufort Court, West Bridgford, Nottinghamshire, NG2 7TB,United Kingdom

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ksj.ksj_21_20

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Well-differentiated thyroid cancers are usually managed by total thyroidectomy with or without neck dissection. High-risk patients are followed up using serial thyroglobulin estimation and radioiodine scans. The phenomenon of dedifferentiation is essential to understand the events during post-operative follow-up of these tumours. This article describes the cascade of sequential dedifferentiation, its genetic undercurrents and its impact on the detection and treatment of post-surgical recurrences. New targeted agents aimed at redifferentiation are also discussed.

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